Bonjour, je suis le Dr Marc Deloger, Responsable de la plateforme bioinformatique de Gustave Roussy.

Voici quelques-unes de mes publications scientifiques

Elevated calprotectin and abnormal myeloid cell subsets discriminate severe from mild COVID-19Blood myeloid cells are known to be dysregulated in the coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2. It is unknown whether the innate mye…

Small Cell Carcinoma of the Ovary, Hypercalcemic Type (SCCOHT) beyond SMARCA4 Mutations: A Comprehensive Genomic AnalysisSmall cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is an aggressive malignancy that occurs in young women, is characterized by recurrent loss-of-function mutations in the SMARCA4 gene, and for which effective treatments options are lacking. ...

Mechanistic Signatures of Human Papillomavirus Insertions in Anal Squamous Cell CarcinomasThe role of human papillomavirus (HPV) in anal squamous cell carcinoma (ASCC) carcinogenesis has been clearly established, involving the expression of viral oncoproteins and optional viral DNA integration into the host genome. In this article, we describe ...

XPO1 regulates erythroid differentiation and is a new target for the treatment of β-thalassemia - PubMedβ-thalassemia major (β-TM) is an inherited haemoglobinopathy caused by a quantitative defect in the synthesis of β-globin chains of haemoglobin, leading to the accumulation of free α-globin chains that aggregate and cause ineffective erythropoiesis. We have previously demonstrated that terminal eryt …

Genetic Diversity and Gene Family Expansions in Members of the Genus EntamoebaAmoebiasis is the third-most common cause of mortality worldwide from a parasitic disease. Although the primary etiological agent of amoebiasis is the obligate human parasite Entamoeba histolytica, other members of the genus Entamoeba can infect humans ...

Added Value of Whole-Exome and Transcriptome Sequencing for Clinical Molecular Screenings of Advanced Cancer Patients With Solid Tumors - PubMedComprehensive genomic profiling using high-throughput sequencing brings a wealth of information, and its place in the clinical setting has been increasingly prominent. This review emphasizes the utility of whole-exome sequencing (WES) and transcriptome sequencing (RNAseq) in patient care and clinica …

HEMO, an ancestral endogenous retroviral envelope protein shed in the blood of pregnant women and expressed in pluripotent stem cells and tumorsEndogenization of retroviruses has occurred multiple times in the course of vertebrate evolution, with the captured retroviral envelope syncytins playing a role in placentation in mammals, including marsupials. Here, we identify an endogenous retroviral ...

Molecular Screening for Cancer Treatment Optimization (MOSCATO-01) in Pediatric Patients: A Single-Institutional Prospective Molecular Stratification Trial - PubMed<span><b>Purpose:</b> This single-institutional feasibility study prospectively characterized genomic alterations in recurrent or refractory solid tumors of pediatric patients to select a targeted therapy.<b>Experimental Design:</b> Following treatment failure, patients with signed consent and ages above</span> …

Mutational Profile of Metastatic Breast Cancers: A Retrospective AnalysisMajor advances have been achieved in the characterization of early breast cancer (eBC) genomic profiles. Metastatic breast cancer (mBC) is associated with poor outcomes, yet limited information is available on the genomic profile of this disease. This ...

Circulating Cell-Free Tumor DNA Analysis of 50 Genes by Next-Generation Sequencing in the Prospective MOSCATO Trial - PubMedDetection of somatic mutations in cfDNA is feasible for prescreening phase I candidates with a satisfactory specificity; overall sensitivity can be improved by a sensitivity score allowing to select patients for whom cfDNA constitutes a reliable noninvasive surrogate to screen mutations. Clin Cancer …

Quantification of stochastic noise of splicing and polyadenylation in Entamoeba histolyticaAlternative splicing and polyadenylation were observed pervasively in eukaryotic messenger RNAs. These alternative isoforms could either be consequences of physiological regulation or stochastic noise of RNA processing. To quantify the extent of stochastic ...

Next generation sequencing reveals genome downsizing in allotetraploid Nicotiana tabacum, predominantly through the elimination of paternally derived repetitive DNAs - PubMedWe used next generation sequencing to characterize and compare the genomes of the recently derived allotetraploid, Nicotiana tabacum (<200,000 years old), with its diploid progenitors, Nicotiana sylvestris (maternal, S-genome donor), and Nicotiana tomentosiformis (paternal, T-genome donor). Analy …

Identification of expressed transposable element insertions in the sequenced genome of Drosophila melanogaster - PubMedTransposable elements (TEs) are major components of most genomes, and their impact on genome evolution is now well documented. However, the way they affect the transcriptome is still not clearly established. Using the sequenced genome of Drosophila melanogaster and EST libraries, we describe here th …

A Genomic Distance Based on MUM Indicates Discontinuity between Most Bacterial Species and Genera The fundamental unit of biological diversity is the species. However, a remarkable extent of intraspecies diversity in bacteria was discovered by genome sequencing, and it reveals the need to develop clear criteria to group strains within a species. Two ...

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Contactez-moi à cette adresse : marc.deloger@gustaveroussy.fr

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